The Major PGD Milestones:

• 1968:
  Sexing of Rabbit Embryos at the Blastocyst Stage



• 1978:
  Birth of the First IVF Baby



• 1990:
  Sexing Human Preimplantation Embryo, & Polar Body Analysis for Mendelian Disease; First PGD Baby Born



• 1993:
  FISH Analysis for Sexing and for PGD of Aneuploidies



• 1996:
  PGD for Chromosomal Translocations



• 1999:
  PGD for Late Onset Common Disorders with Genetic Predisposition



• 2000:
  Preimplantation HLA Typing



• 2002:
  First Thousand PGD Babies Born (see Figure 1)



• 2009:
  PGD for Chromosomal Disorders by Microarray-Based Technology



• 2013:
  Next Generation Sequecing for Preimplantation Aneuploidy Testing